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Quality Factory Supply 99% Pure DL-2-AMINOOCTANOIC ACID 644-90-6 with Efficient Delivery
- Molecular Formula: C8H17NO2
- Molecular Weight: 159.228
- Appearance/Colour: White powder
- Melting Point: 260 °C (dec.)(lit.)
- Refractive Index: 1.4630 (estimate)
- Boiling Point: 267.8 °C at 760 mmHg
- PKA: 2.55±0.24(Predicted)
- Flash Point: 115.8 °C
- PSA: 63.32000
- Density: 0.999 g/cm3
- LogP: 2.06900
DL-2-AMINOOCTANOIC ACID(Cas 644-90-6) Usage
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General Description |
DL-2-Aminooctanoic acid (also known as α-aminooctanoic acid) is an α-amino fatty acid used in the synthesis of polyoxin L analogues with potential anticandidal activity. In this study, it was incorporated into dipeptidyl polyoxin L derivatives to enhance affinity for peptide transport systems and stability against intracellular degradation in *Candida albicans*. The resulting analogues demonstrated inhibitory effects on chitin synthetase and were recognized by the fungal dipeptide transport system, though their clinical efficacy may be limited due to moderate potency. |
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Definition |
ChEBI: An alpha-amino fatty acid that is caprylic acid which is substituted at position 2 by an amino group. |
InChI:InChI=1S/C8H17NO2/c1-2-3-4-5-6-7(9)8(10)11/h7H,2-6,9H2,1H3,(H,10,11)
644-90-6 Relevant articles
Hexyl-modified morpholine-2,5-dione-based oligodepsipeptides with relatively low glass transition temperature
Peng, Xingzhou,Behl, Marc,Zhang, Pengfei,Mazurek-Budzyńska, Magdalena,Razzaq, Muhammad Yasar,Lendlein, Andreas
, p. 318 - 326 (2016/11/18)
Oligodepsipeptides (oDPs), alternating c...
New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in Aspergillus nidulans
Henke, Matthew T.,Soukup, Alexandra A.,Goering, Anthony W.,McClure, Ryan A.,Thomson, Regan J.,Keller, Nancy P.,Kelleher, Neil L.
, p. 2117 - 2123 (2016/08/30)
Unlocking the biochemical stores of fung...
Biocatalytic asymmetric synthesis of unnatural amino acids through the cascade transfer of amino groups from primary amines onto keto acids
Park, Eul-Soo,Dong, Joo-Young,Shin, Jong-Shik
, p. 3538 - 3542 (2014/01/06)
Flee to the hills: An unfavorable equili...
Microwave-assisted synthesis of unnatural amino acids
Young, Douglas D.,Torres-Kolbus, Jessica,Deiters, Alexander
experimental part, p. 5478 - 5480 (2009/05/30)
Microwave irradiation has been proven to...
644-90-6 Process route
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2-leucylamino-octanoic acid
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61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine
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-
644-90-6,2187-07-7
2-aminooctanoic acid
| Conditions | Yield |
|---|---|
|
bei der Einw. von Hefemacerationssaft;
|
-
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306748-50-5
2-glycylamino-octanoic acid
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-
644-90-6,2187-07-7
2-aminooctanoic acid
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-
56-40-6,18875-39-3,25718-94-9
glycine
| Conditions | Yield |
|---|---|
|
bei der Einw. von Hefemacerationssaft;
|
644-90-6 Upstream products
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74-90-8
hydrogen cyanide
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40899-00-1
1-amino-heptan-1-ol
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880141-72-0
2-formylamino-octanoic acid
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2623-82-7
2-bromooctanoic acid
644-90-6 Downstream products
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6271-04-1
4-hexyl-oxazolidine-2,5-dione
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761343-79-7
α-hexylglycine ethyl ester
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92211-95-5
2-((tertbutoxycarbonyl)amino)octanoic acid
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106819-03-8
(R)-α-aminooctanoic acid
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